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Are you suffering from chronic knee pain or been diagnosed with osteoarthritis (OA) of the knee?
Do you wish you could decrease or eliminate your pain medications?
Have you had side effects or were told that you cannot take certain arthritis pain medications?
Do you want to put off or avoid knee replacement surgery?
Are you worried about pain after your upcoming knee replacement surgery?
    If you answered “YES” to any of the questions above, you may want to learn more about Iovera, a NEW FDA cleared
    treatment for peripheral nerve pain.  Your peripheral nerves sense pain. Iovera temporarily freezes your nerves so that the
    pain signal is BLOCKED and can provide significant pain relief on average from 2-4 months.  The pain will return once your
    nerve heals and grows back.
    Unlike cortisone or visco-supplementation injections, NO MEDICINE is injected into your body (joint) which decreases
    medication side effects and eliminates your risk of developing a joint infection that can be serious and require surgery.
Focused Cold Therapy
for Knee Pain
Please call (510) 791-1300 and ask for the Iovera Specialist, to schedule your cold focused therapy injection today!
Works To
Away Knee
(YouTube clip)
Success Stories
Iovera in the News - CBS, ABC, and more to come...
How does the iovera° treatment work?
The iovera° treatment works by applying targeted cold to a peripheral nerve which immediately
prevents the nerve from sending pain signals. The effect of the cold on the nerve is temporary and
does not cause permanent damage because it leaves the structural components of the nerve
intact. The nerve is restored to function after several months.

What kind of results can I expect?
The iovera° treatment is very precise and when targeted cold is applied to a specific nerve, it will
immediately interrupt that nerve’s ability to signal. Duration and degree of pain relief is dependent
on each patient’s unique condition. We will discuss your specific case with you.

Are there any side effects?
Side effects are similar to those of other minimally invasive, needle-based treatments and typically
resolve within a few days. Common side effects include local pain, crusting, pigmentation changes,
bruising and tingling. In rare cases, numbness or tingling of nearby sensory nerves may be
affected for longer periods of time.

How long does it last?
The duration of the pain relief depends on the location of the nerve being treated; however, results
from treatment typically last up to three months.
habits, to reduce the many contributing factors
to their pain.

The immediate & dramatic pain reduction
that Iovera provides is a powerful motivator
for behavioral change that I believe will
transform the course of pain management
from the passive use of medication to an
active partnership between doctors and

- Barry Shibuya MD
- Fremont Rheumatology and Fremont Holistic Center,
Fremont, CA
Fremont Rheumatology
Arthritis, Osteoporosis, and Auto-Immune Diseases
Barry Shibuya M.D.  and  Christine Elias M.D.